Single-fraction stereotactic ablative body radiation therapy for primary and metastasic lung tumor: A new paradigm?

Table 3 Benefits and constraints to using single fraction stereotactic ablative body radiotherapy schemes

Benefits	Constraints
Low medium-long term toxicity	Fear of severe toxicity in initial studies
Prospective efficacy and toxicity data	Insufficient long-term data
Convenience for patient, fewer hospital visits (indirect costs), shorter treatment times
Less occupation of accelerators
Reduced positioning errors between fractions	Greater risk of positioning errors
Peripheral tumors	Central tumors
Reduction in direct costs
Less interference with systemic therapies	Cases of Neumonitis recall with some systemic therapies
Convenience for COVID-19 pandemic