Review
Copyright ©The Author(s) 2022.
World J Clin Oncol. Nov 24, 2022; 13(11): 866-879
Published online Nov 24, 2022. doi: 10.5306/wjco.v13.i11.866
Figure 2
Figure 2 Simplified model of CagA-mediated hit-and-run carcinogenesis. The pro-oncogenic properties of CagA are already well established. However, genetic and epigenetic alterations caused by this oncoprotein provide a favorable environment for carcinogenesis, independently of its presence, in a hit-and-run carcinogenesis mechanism. In this sense, through interaction with various host proteins, CagA leads to chromosomal instability, double-strand breaks and repeated nucleotide mutations, which are correlated to gastric cancer development. CMW: western CagA.