Association of cancer with comorbid inflammatory conditions and treatment in patients with Lynch syndrome

Table 1 Demographics, genetic diagnosis, surveillance, surgical history, and cancer in hereditary non-polyposis colorectal cancer

	Inflammatory disease present, n = 21	Controls, n = 43	P value
Current age (yr), mean ± SD	53.9 ± 15.7	53.8 ± 7.8	0.97
Gender, n (%)
Female	12 (57.1)	25 (58.1)	0.94
Race, n (%)
White	17 (81.0)	40 (93.0)	0.34
Black	1 (4.8)	1 (2.3)
Others	3 (14.3)	2 (4.6)
Smoking Status, n (%)
Former/current	9 (42.9)	20 (46.5)
Never Smoker	12 (57.1)	23 (53.5)	0.72
Family History of Cancer, n (%)
Colon	13 (61.9)	33 (78.6)	0.16
LS Cancer	11 (52.4)	24 (57.1)	0.72
Other cancers	12 (57.1)	25 (58.1)	0.94
LS MMRPV, n (%)	14 (66.7)	21 (67.4)	1
MLH1	5 (23.8)	10 (23.3)
MSH2	3 (14.3)	7 (16.3)
MSH6	2 (9.5)	4 (9.3)
PMS2	4 (19.0)	8 (18.6)
No MMRPV	7 (33.3)	14 (32.6)
Age of HNPCC diagnosis, mean ± SD
LS	43.6 ± 14.0	45.4 ± 7.6	0.66
No MMRPV	49.0 ± 5.4	46.3 ± 2.2	0.59
Screening colonoscopies
Median total number	5 (IQR 3.0-6.0)	4 (IQR 2.0-6.0)	0.19
Median years between colonoscopies	1.0 (IQR 1.0-1.5)	1.0 (IQR 1.0-1.6)	0.87
History of complete or partial colectomy	15 (76.2)	23 (53.5)	0.08
TAH-BSO (% of females in each group)	10 (83.3)	19 (76.0)	0.8
History of Prophylactic TAH-BSO (% of females in each group)	6 (50.0)	7 (28.0)	0.27
Proportion of patients with any cancer, n (%)	16 (84.2)	33 (76.7)	0.74
Cancer Incidence-10 yr follow up	12 (57.1)	20 (46.5)	0.42
Age at Diagnosis of first cancer (yr), mean ± SD	45.5 ± 14.6	43.8 ± 7.1	0.67

HNPCC: Hereditary non-polyposis colorectal cancer; LS: Lynch syndrome; MMRPV: Mismatch repair pathogenic variant; TAH- BSO: Total abdominal hysterectomy-bilateral salpingo-oophorectomy.