Re-irradiation for high-grade gliomas: Has anything changed?

Table 5 Scoring scheme and new prognostic groups of the “New Combs Score”

Prognostic factors	Prognostic value
Primary histology
Glioblastoma, WHO IV	2
Anaplastic glioma, WHO III	1
Low-grade glioma, WHO I/II	0
Age
≥ 50 yr	1
< 50 yr	0
Time between primary RT and re-RT
≤ 12 meses	1
> 12 meses	0
Re-resection performed
No	1
Yes	0
KPS
< 80%	1
≥ 80%	0
Tumor volume (PTV)
> 47 mL	1
≤ 47 mL	0
Scoring group	Scoring value/mOS
a	0–1/19.5 mo
b	2–3/11.3 mo
c	4–5/8.1 mo
d	6–7/5.5 mo

KPS: Karnofsky performance status; mOS: Median overall survival; PTV: Planning target volume; RT: Irradiation; WHO: World Health Organization.