Re-irradiation for high-grade gliomas: Has anything changed?

Table 1 Summary of selected publications reporting radiosurgery as salvage treatment in recurrent high-grade gliomas

Ref.	Study type	No. patients	Histology	Re-irradiation		Median interval	Median tumor volume	Median PFS2	Median OS2	Severe toxicity	Radionecrosis
				Total dose, median	Dose/fr, median
Combs et al[28], 2005	R	32	All GBM	15 Gy	63.8 Gy	10 mo	10 mL	7 mo	10 mo	0%	0%
Hsieh et al[104], 2005	R	26	All GBM	12 Gy	42 Gy	NR	21.6 mL	NR	10 mo	NR	31.3% by image
Kong et al[34], 2008	P	114	65 GBM, 49 G3G	16 Gy	72 Gy	NR	10.6 mL	4.6 mo (GBM), 8.6 mo (G3G)	13 mo (GBM), 26 mo (G3G)	0%	24.4% by image
Patel et al[68], 2009	R	26	All GBM	18 Gy	90 Gy	12.5 mo	10.4 mL	NR	8.4 mo	Limited toxicity	NR
Skeie et al[30], 2012	R	51	All GBM	12.2 Gy	43.3 Gy	11 mo	12.4 mL	6 mo	12 mo	0%	0%
Martínez-Carrillo et al[31], 2014	R	87	46 GBM, 41 G3G	18 Gy	90 Gy	13.8 mo	8.7 mL	NR	7.5 mo (GBM); 17 mo (G3G)	0%	0%
Kim et al[105], 2015	R	29	All GBM	15 Gy	63.8 Gy	8.8 mo	11 mL	3.6 mo	9.2 mo	NR	NR

α/β = 2; EQD2: Equivalent dose at 2 Gy fractions; G3G: Grade III glioma; GBM: Glioblastoma; NR: Not reported; OS2: Overall survival from re-irradiation; P: Prospective; PFS2: Progression free survival from re-irradiation; R: Retrospective.