Adjuvant therapy for lung neuroendocrine neoplasms

Table 1 Summary of current available guidelines for the use of adjuvant therapy in the treatment of stage I, II, and III typical carcinoid and atypical carcinoid

Stage; Subgroup	Guidelines
	CommNETS/NANETS	ENETS	NCCN	ESMO
I; TC	Surgery without AT	Surgery without AT	Surgery without AT	Surgery without AT
I; AC	Surgery without AT	Surgery without AT	Surgery without AT	Surgery without AT
II; TC	Surgery without AT	Surgery without AT	Surgery without AT	Surgery without AT
II; AC	Surgery without AT	Surgery without AT	Surgery without AT	Surgery without AT
III; TC	Surgery without AT	Surgery without AT	Surgery without AT	Surgery without AT
III; AC	Surgery without AT	Chemotherapy may be considered in patients with positive lymph nodes	Chemotherapy may be considered. RT is not recommended	Chemotherapy with or without radiation therapy may be considered in patients who are at high risk of relapse, (ex: N2 patients)

AT: Adjuvant therapy; AC: Atypical carcinoid; ENETS: European Neuroendocrine Tumor Society; ESMO: European Society of Medical Oncology; CommNETS: Commonwealth Neuroendocrine Tumour Research Collaboration, NANETS: North American Neuroendocrine Endocrine Tumor Society; NCCN: National Comprehensive Cancer Network; NR: No recommendations; TC: Typical carcinoid.