Liver transplantation in malignant disease

Table 2 2007 Milan neuroendocrine tumor criteria[143]

Inclusion criteria
Histology G1/G2 neuroendocrine tumor with or without syndrome
Primary tumor drained by the portal system (pancreas and intermediate gut: from distal stomach to sigmoid colon)
Primary tumor removed with a curative resection (pretransplant removal of all extrahepatic tumor deposits) through surgical procedures separate from transplantation
Less than 50% tumor load in the liver parenchyma
Response to treatment or stable disease for at least 6 mo pretransplantation
Age younger than 55 yr (relative criteria)
Exclusion criteria
High-grade neuroendocrine carcinomas
General contraindications for liver transplantation, including previous tumors
Non-gastrointestinal NET or tumors not drained by the portal system

NET: Neuroendocrine tumor.