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Copyright ©The Author(s) 2021.
World J Clin Oncol. Jul 24, 2021; 12(7): 557-564
Published online Jul 24, 2021. doi: 10.5306/wjco.v12.i7.557
Table 2 Potential advantages (+) and disadvantages (-) of preoperative chemoradiation and perioperative chemotherapy
Preoperative chemoradiotherapyPerioperative chemotherapy
+ Better loco-regional control+ Better systemic control
+ High rates of complete pathologic response+ No adverse events from radiotherapy
- Poorer response in adenocarcinoma (increased radiation sensitivity in squamous cell carcinoma)- Poorer loco-regional control
- Radiation-induced changes in surgical field- Many patients are not able to complete the postoperative regimen