Modulation of the immune response by heterogeneous monocytes and dendritic cells in lung cancer

Table 1 Clinical trials with dendritic cell vaccine in lung cancer patients on the basis of clinical trials registry

Status	Major trial	Condition	Study intervention	Official trial code
Recruiting	MIDRIXNEO	NSCLC	Dendritic cell immunotherapy	NCT04078269[132]
Recruiting	MIDRIX4-LUNG	Metastatic NSCLC	Dendritic cell immunotherapy	NCT04082182[132]
Completed	Vaccine Therapy in Treating Patients With Stage I, Stage II, or Stage III Non-small Cell Lung Cancer	Lung cancer	Autologous dendritic cell cancer vaccine	NCT00103116[133,134]
Recruiting	Combination Immunotherapy-Ipilimumab-Nivolumab-Dendritic Cell p53 Vac-Patients With SCLC	SCLC; Lung cancer; Relapsed	Combination immunotherapy with Ipilimumab and Nivolumab plus a Dendritic Cell based p53 Vaccine	NCT03406715
Completed	Dendritic Cells in Lung Cancer	NSCLC	Allogeneic Tumour Lysate	NCT00442754
Completed	Chemotherapy Followed By Vaccine Therapy in Treating Patients With Extensive-Stage Small Cell Lung Cancer	Lung cancer	Autologous dendritic cell-adenovirus p53 vaccine combined with Carboplatin and Etoposide	NCT00049218
Completed	Vaccine Therapy in Treating Patients With Stage IIIB, Stage IV, or Recurrent NSCLC	Lung cancer	Autologous dendritic cell-adenovirus CCL21 vaccine	NCT00601094
Completed	CSET 1437	NSCLC	Dendritic cell-derived exosomes	NCT01159288
Completed	Vaccine Therapy in Treating Patients With Stage IIINSCLC	Lung cancer	Mutant p53 peptide pulsed dendritic cell vaccine combined with adjuvant therapy	NCT00019929
Completed	Vaccine Therapy in Treating Patients With NSCLC	Lung cancer	Autologous tumor cell vaccine therapeutic autologous dendritic cells combined with conventional surgery	NCT00023985
Recruiting	AST-VAC2 Vaccine in Patients With NSCLC	NSCLC in the advanced and adjuvant settings	AST-VAC2 Vaccine	NCT03371485
Recruiting	Luscid	NSCLC	Pembrolizumab with or without intratumoral avelumab/ipilimumab plus CD1c (BDCA-1)+/CD141 (BDCA-3) + myeloid dendritic cells	NCT04571632
Completed	To Immunize Patients With Extensive Stage SCLC Combined With Chemo With or Without ATRA	SCLC	Paclitaxel Ad.p53-DC vaccines. ATRA	NCT00617409
Completed	Denileukin Diftitox Followed by Vaccine Therapy in Treating Patients With Metastatic Cancer	Lung cancer; Breast cancer; Colorectal cancer; Pancreatic cancer	Denileukin diftitox recombinant fowlpox-CEA(6D)/TRICOM vaccine therapeutic autologous dendritic cells	NCT00128622
Completed	Biological Therapy in Treating Patients With Metastatic Cancer	Lung cancer; Breast cancer; Colorectal cancer; Extrahepatic Bile Duct cancer; Gallbladder cancer; Gastric cancer; Head and Neck cancer; Liver cancer; Ovarian cancer; Pancreatic cancer	CEA RNA-pulsed DC cancer vaccine	NCT00004604
Completed	Vaccine Therapy and Biological Therapy in Treating Patients With Advanced Cancer	Lung cancer; Breast cancer; Cervical cancer; Colorectal cancer; Ovarian cancer; Pancreatic cancer	Combining DCs vaccine therapy with interleukin-2	NCT00019084

NSCLC: Non small lung cancer; SCLC: Small cell lung cancer; CCL21: Chemokine C-C motif ligand 21; ATRA: All trans retinoic acid.