Human epidermal growth factor receptor 2 targeted therapy in endometrial cancer: Clinical and pathological perspectives

Table 1 Human epidermal growth factor receptor 2 overexpression and gene amplification in endometrial cancer

Histological type	HER2 overexpression	HER2 gene amplification	Ref.
Overall	4%-69%	18%-80%	[19,45,55]
Endometrioid (low grade)	rare	rare	[29,45]
Endometrioid (high grade)	8%-31%	15%-29%	[29,45]
Serous carcinoma	20%-60%	13%-29%	[29,42,43,45]
Clear cell carcinoma	33%-70%	22%-50%	[29,55]
Carcinosarcoma	0-25%	13%-20%	[38,48-51]