Human epidermal growth factor receptor 2 positive rates in invasive lobular breast carcinoma: The Singapore experience

doi:10.5306/wjco.v11.i5.283

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. May 24, 2020; 11(5): 283-293
Published online May 24, 2020. doi: 10.5306/wjco.v11.i5.283

Table 1 Clinical and histopathological characteristics of human epidermal growth factor receptor 2 positive and human epidermal growth factor receptor 2 negative invasive lobular carcinomas patients, n (%)

Characteristics	HER2+ (n = 87)	HER2- (n = 777)		Total (n = 864)	P value
Age (yr)					1.000
≤ 50	30 (34.5)	272 (35.0)		302 (35.0)
> 50	57 (65.5)	505 (65.0)		562 (65.0)
Ethnicity					0.594
Chinese	68 (78.2)	558 (72.1)		626 (72.7)
Indian	4 (4.6)	60 (7.8)		64 (7.4)
Malay	8 (9.2)	68 (8.8)		76 (8.8)
Others	7 (8.0)	88 (11.4)		95 (11.0)
ER					< 0.001
Negative	21 (24.4)	46 (5.9)		67 (7.8)
Positive	65 (75.6)	730 (94.1)		795 (7.8)
PR					0.002
Negative	35 (40.2)	185 (24.0)		220 (25.6)
Positive	52 (59.8)	587 (76.0)		639 (74.4)
Tumour size					0.765
0.1-2 cm	21 (41.2)	230 (38.7)		251 (38.9)
> 2 cm	30 (58.8)	365 (61.3)		395 (61.1)
Tumour grade					<0.001
Grade 1	7 (10.1)	148 (22.5)		155 (21.3)
Grade 2	42 (60.9)	443 (67.3)		485 (66.7)
Grade 3	20 (29.0)	67 (10.2)		87 (12.0)
Tumour stage					0.066
Stage 1	20 (24.1)	216 (30.3)		236 (29.7)
Stage 2	25 (30.1)	267 (37.5)		292 (36.7)
Stage 3	27 (32.5)	179 (25.1)		206 (25.9)
Stage 4	11 (13.3)	50 (7.0)		61 (7.7)
Treatment
Chemotherapy¹	50 (66.7)	390 (54.2)		440 (55.3)	0.038
With HER2 therapy	47 (54.0)	-	-	47 (54.0)
No HER2 therapy	12 (13.8)	-	-	12 (13.8)
Unknown if any HER2 therapy	28 (32.2)	-	-	28 (32.2)
Radiotherapy²	47 (62.7)	404 (56.1)		451 (56.7)	0.276
Surgery³	73 (92.4)	690 (92.1)		763 (92.1)	0.929

¹There were 69 patients with unknown chemotherapy histories which were excluded from analysis.

²There were 69 patients with unknown radiotherapy histories which were excluded from analysis.

³There were 36 patients with unknown surgery histories which were excluded from analysis. HER2: Human epidermal growth factor receptor 2; HER2+: Human epidermal growth factor receptor 2 positive; HER2-: Human epidermal growth factor receptor 2 negative; ER: Estrogen receptor; PR: Progesterone receptor.

Citation: Kee GJ, Tan RYC, Rehena S, Lee JJX, Zaw MWW, Lian WX, Yeong J, Tan SM, Lim SH, Tan BKT, Yap YS, Dent RA, Wong FY, Lee GE. Human epidermal growth factor receptor 2 positive rates in invasive lobular breast carcinoma: The Singapore experience. World J Clin Oncol 2020; 11(5): 283-293
URL: https://www.wjgnet.com/2218-4333/full/v11/i5/283.htm
DOI: https://dx.doi.org/10.5306/wjco.v11.i5.283