Role of Mediterranean diet in preventing platinum based gastrointestinal toxicity in gynecolocological malignancies: A single Institution experience

Table 4 Gastrointestinal toxicities’ score after first chemotherapy cycle in the whole study population and in the two study’s groups according to the Mediterranean diet serving score

	MDSS ≥ 13	MDSS < 13	Total	P value
Dry mouth (G)	1 ± 1.3	1.1 ± 1.3	1 ± 1.3	0.85
Dysphagia (G)	0.3 ± 0.5	0.4 ± 0.7	0.3 ± 0.6	0.70
Oral sores (A)	0.2 ± 0.4	0.5 ± 1.3	0.3 ± 0.9	0.45
Oral sores (G)	0.1 ± 0.3	0.4 ± 1.3	0.2 ± 0.9	0.44
Mouth’s cracks (G)	0.1 ± 0.3	0.4 ± 1.3	0.2 ± 0.9	0.44
Dysgeusia (G)	0.9 ± 1.2	1 ± 1.2	1 ± 1.2	0.84
Loss of appetite (I.A)	1.1 ± 1.1	1.4 ± 1.5	1.2 ± 1.3	0.59
Loss of appetite (G)	1 ± 1	1.3 ± 1.7	1.1 ± 1.3	0.61
Nausea (F)	1.5 ± 1.1	1.4 ± 1.6	1.5 ± 1.3	0.86
Nausea (G)	1 ± 0.9	1.5 ± 1.7	1.2 ±1.3	0.38
Vomiting (F)	0.6 ± 0.8	0.6 ± 1.3	0.6 ± 1	1
Vomiting (G)	0.3 ± 0.5	0.6 ± 1.3	0.5 ± 1	0.46
Stomachache (F)	0.2 ± 0.6	0.7 ± 0.9	0.4 ± 0.8	0.13
Stomachache (G)	0.1 ± 0.3	0.5 ± 0.7	0.3 ± 0.6	0.08
Intestinal gas (yes/no)	0.4 ± 0.5	0.3 ± 0.5	0.4 ± 0.5	0.64
Bloating (F)	0.7 ± 0.9	0.5 ± 1	0.6 ± 0.9	0.62
Bloating (G)	0.3 ± 0.5	0.4 ± 0.7	0.4 ± 0.6	0.70
Constipation (G)	0.5 ± 0.5	0.7 ± 0.7	0.6 ± 0.6	0.44
Diarrhea (F)	0.7 ± 0.9	0.7 ± 1.3	0.7 ± 1.1	1
Abdomen ache (F)	1.1 ± 1	0.3 ± 0.7	0.7 ± 0.9	0.04
Abdomen ache (G)	0.8 ± 0.8	0.2 ± 0.4	0.5 ± 0.7	0.04
Abdomen ache (I.A)	0.7 ± 0.8	0.2 ± 0.6	0.5 ± 0.7	0.11
Toxicity (TOT)	13.4 ± 6.6	15.1 ± 14.5	14.2 ± 10.7	0.7

I.A: Interference with daily activities; MDSS: Mediterranean diet serving score; G: Gravity; F: Frequency; TOT: Time of treatment.