Germline mutations in Thai patients with nonmucinous epithelial ovarian cancer

Table 3 Frequency of germline mutations according to various clinical risk factors

Risk factors	Number of patients	BRCA1, n (%)	BRCA2, n (%)	Other genes, n (%)
None	30	0	0	0
Family history of cancers (breast/ovary/endometrium/colon)	32	10 (31.2)	4 (12.5)	4 (12.5) (1ATM, 1RAD51C,1 MLH1, 1MSH2)
Family history of breast cancer	22	6 (27.3)	3 (13.6)	0
Family history of ovarian cancer	10	5 (50.0)	1 (10.0)	1 (10.0) (RAD51C)
Personal history of breast cancer	12	0	3 (25.0)	1 (8.3) (ATM)
Two primary ovarian and endometrial cancer	9	0	0	3 (33.3) (1 MLH1, 1MSH2, 1CDH1)
High-grade serous carcinoma	49	14 (28.6)	5 (10.4)	1 (2.1) (RAD51C)
Young age (< 40 yr)	14	1 (7.1)	1 (7.1)	0