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©2014 Baishideng Publishing Group Inc.
World J Biol Chem. May 26, 2014; 5(2): 216-223
Published online May 26, 2014. doi: 10.4331/wjbc.v5.i2.216
Published online May 26, 2014. doi: 10.4331/wjbc.v5.i2.216
Table 1 Sequences of Cdc4 phospho-degrons in FBW7 substrates
| Substrate | Cdc4 phospho-degron | Phospho-site |
| CyclinE | LLTPPQSG | T380 S384 |
| Myc | LPTPPLSP | T58 S62 |
| JUN | GETPPLSP | T239 S243 |
| NOTCH1 | FLTPSPE | T2512 |
| TGIF | FNTPPPTP | T235 T239 |
| SRC3 | VHSPMASS | S505 S509 |
| mTOR | LLTPSIHL | T631 |
| MCL1 | DGSLPSTP | S159 T163 S121 |
| KLF5 | LNTPDLDM/PPSPPSSE/ NLTPPPSY | T244 S303 T324 |
| KLF2 | PDTPPLSPD/LLTPPSSP | T171 S175 T243 S247 |
| SREBP | TLTPPPSDAGSP | T426 S430 S434 |
| SV40 large T antigen | PPTPPPEP | T701 |
| MED13/MED13L | SSVTLTPPTS | T326 |
| NF-κB2 | LPSPPTSDSDSD | S707 S711 |
| C/EBPα | HPTPPPTP | T222 T226 |
| C/EBPσ | QPTPPQSP | T157 S161 |
| HIF1a | DQTPSPSDGSTRQSS | T497 S451 |
| AuroraA | LSYCHSK/NSSKPSN | S245 S387 |
| C-Myb | LMTPVSED | T572 S556 S528 |
| NRF1 | LFSPEVE | S350 |
| PGC1 | PLTPESPN/GLTPPTTP | T263 T295 |
- Citation: Luan Y, Wang P. FBW7-mediated ubiquitination and degradation of KLF5. World J Biol Chem 2014; 5(2): 216-223
- URL: https://www.wjgnet.com/1949-8454/full/v5/i2/216.htm
- DOI: https://dx.doi.org/10.4331/wjbc.v5.i2.216