PDRG1 at the interface between intermediary metabolism and oncogenesis

Figure 2 Regulatory elements on the human PDRG1 gene and mRNA and structural features of the protein. From top to bottom, the figure shows first a scheme of the human PDRG1 gene, indicating the regulatory elements on the promoter identified to date as follows: p53 and p53TRE elements (red), an Oct-1 binding element (green) and the TATA-box-like element (crimson). Exons appear as blue boxes. Second, a schematic representation of the mRNA is depicted, including the ORF (blue box) and the miRNA binding sites identified at the 3’-UTR (aquamarine boxes). Third, a scheme of the PDRG1 protein is shown where the sequence encoding the prefoldin-like domain is indicated as a crimson box. Finally, a cartoon of the modeled prefoldin-like domain of rat PDRG1 is included with the N-terminal K27 (red) and the C-terminal Q106 (magenta) depicted as sticks.