Multifunctional facets of retrovirus integrase

Figure 9 Identification of strand transfer inhibitor-trapped Rous sarcoma virus synaptic complex by size-exclusion chromatography. A: Schematic of Rous sarcoma virus (RSV) IN, 3’ OH recessed ODN, and strand transfer inhibitor (STI) used to assemble STI-trapped synaptic complex (SC); B: MK-2048 and Dolutegravir (DTG) efficiently produce trapped SC while Raltegravir had moderate efficiency. No trapped SC is produced in the absence of STI. Elution positions of STI-trapped SC (red line), free IN and DNA are marked. Molecular weight markers are indicated.