Multifunctional facets of retrovirus integrase

doi:10.4331/wjbc.v6.i3.83

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 6, Issue 3

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (9363)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-9) series.

Item

Count

PDF

603

WORD

295

HTML

6222

Figures (1-9)

238

Sum=7358

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

899

Download

1106

Sum=2005

Aug 26, 2015 (publication date) through May 18, 2024

Times Cited of This Article

Times Cited (8)

Journal Information of This Article

Publication Name

World Journal of Biological Chemistry

ISSN

1949-8454

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Review

World J Biol Chem. Aug 26, 2015; 6(3): 83-94
Published online Aug 26, 2015. doi: 10.4331/wjbc.v6.i3.83

Full Size Figure Download Figure

Figure 4 Selection of cellular DNA target sites for integration. Left: IN within the PIC is guided to host sites by several mechanisms including recognition of weak palindromic sequences by IN, nuclear topography of the cellular host DNA site, chromatin structure, and several kinds of associated histone tails. Only IN (labeled), RT (blue circle) and LEDGF/p75 (gray cylinder) are identified in the figure; Right: Cell proteins (BET and LEDGF/p75) influence the PIC to preferentially insert the viral DNA into specific regions of the host genome. IN: Integrase; PIC: Preintegration complex; HIV: Human immunodeficiency virus; MLV: Murine leukemia virus.

Citation: Grandgenett DP, Pandey KK, Bera S, Aihara H. Multifunctional facets of retrovirus integrase. World J Biol Chem 2015; 6(3): 83-94
URL: https://www.wjgnet.com/1949-8454/full/v6/i3/83.htm
DOI: https://dx.doi.org/10.4331/wjbc.v6.i3.83