Effect of paricalcitol and enalapril on renal inflammation/oxidative stress in atherosclerosis

Figure 4 Western blot analysis and densitometry of protein band analysis to paricalcitol and enalapril alone and in combination for 16-wk on renal iNOS and eNOS protein expression in ApoE-deficient atherosclerotic mice. A: Western blot analysis of the effect of paricalcitol and enalapril alone and in combination for 16-wk on renal iNOS and eNOS protein expression in ApoE-deficient atherosclerotic mice; B: Densitometry of protein band analysis show that renal iNOS expression was significantly enhanced (P < 0.001) whereas eNOS protein expression was significantly decreased (P < 0.001) in ApoE-deficient atherosclerotic mice (n = 3) compared to controls (n = 3). Pricalcitol (n = 3), enalapril (n = 3) and the combination of the two (n = 3) significantly (P < 0.05 and P < 0.001) ameliorated the alterations in iNOS and eNOS expression in atherosclerotic mice. The data represent mean ± SE of three independent Western blot experiments.