Metabolic interplay between glycolysis and mitochondrial oxidation: The reverse Warburg effect and its therapeutic implication

Figure 4 Potential therapeutic targets in metabolic interactions are suggested. A combination therapy might be promising; two targets that block the glycolysis and mitochondrial oxidative phosphorylation or block the glycolysis pathway and amplify ROS levels. Combination treatments targeting both the glycolysis and mitochondrial oxidation, or antioxidant systems can efficiently suppress energy production, or induce ROS-mediated apoptosis. ROS: Reactive oxygen species; MCT: Monocarboxylate transporters.