Review
Copyright ©The Author(s) 2015.
World J Biol Chem. Aug 26, 2015; 6(3): 121-138
Published online Aug 26, 2015. doi: 10.4331/wjbc.v6.i3.121
Table 2 Classification of genes associated with cleft palate in mice
Genes
Signaling pathway
TGF-beta signaling pathwayAcvr1/Alk2, Acvr2a, Bmp41, Bmp7, Bmpr1a/Alk3, Cdc42, Chrd, Crebbp/Cbp, Cited2, Foxc2/Mfh11, Foxd3, Foxe1/Titf2/Fkhl151, Foxf2, Fst, Inhba, Gdf11/Bmp11, Map3k7/Tak1, Pitx2, Smad4, Smad7, Tgfb21, Tgfb31, Tgfbr1/Alk51, Tgfbr21
Hedgehog signaling pathwayBmp41, Bmp7, Crebbp/Cbp, Gli21, Gli31, Gsk3b, Ptch1/Ptc11, Shh1, Smo/Smoh, Wnt5a1, Wnt9b
Wnt signaling pathwayAcvr1/Alk2, Ctnnb1, Crebbp/Cbp, Edn11, Fzd2, Gsk3b, Lrp6, Map3k7/Tak1, Prickle1, Smad4, Smo/Smoh, Wnt5a1, Wnt9b
FGF signaling pathwayFgf10, Fgf18, Fgf9, Fgfr11, Fgfr21, Grb2, Spry1, Spry2
MAPK signaling pathwayCdc42, Chuk/Ikk1/Tcf16, Egfr, Fgf10, Fgf18, Fgf9, Fgfr11, Fgfr21, Grb2, Map3k7/Tak1, Pdgfra1, Tgfb21, Tgfb31, Tgfbr1/Alk51, Tgfbr21, Crk, Itgb1
Cytokine-cytokine receptor interactionAcvr1/Alk2, Acvr2a, Bmp7, Bmpr1a/Alk3, Egfr, Inhba, Pdgfra1, Pdgfc1, Tgfb21, Tgfb31, Tgfbr1/Alk51, Tgfbr21, Vegfa
CBL mediated ligand- induced downregulation of EGF receptorsEgfr, Grb2, Pdgfra1
Sprouty regulation of tyrosine kinase signalsEgfr, Grb2, Spry2, Spry1
NFkB activationCrebbp/Cbp, Chuk/Ikk1/Tcf16, Map3k7/Tak1, Smad4, Tgfbr1/Alk51, Tgfbr21
Adherens junctionCrebbp/Cbp, Ctnnb1, Cdc42, Egfr, Fgfr11, Map3k7/ Tak1, Smad4, Snai2, Tgfbr1/Alk51, Tgfbr21
Focal adhesionCtnnb1, Cdc42, Col2a11, Crk, Egfr, Gsk3b, Grb2, Itga5, Itgb1, Itgb8, Ilk, Pdgfra1, Pdgfc1, Vegfa
Steroid biosynthesisCyp51, Dhcr71, Sc5d/Sc5dl
Cell cycleCrebbp/Cbp, Cdkn1c/p57kip21, Gsk3b, Smad4, Tgfb21, Tgfb31
Regulation of actin cytoskeletonCdc42, Crk, Egfr, Fgf9, Fgf10, Fgf18, Fgfr11, Fgfr21, Itga5, Itgb1, Itgb8, Pdgfra1, Pdgfc1
Axon guidanceCdc42, Efna5, Efnb11, Efnb2, Gsk3b, Itgb1
EndocytosisCdc42, Egfr, Fgfr21, Pdgfra1, Tgfbr1/Alk51, Tgfbr21
AngiogenesisCtnnb1, Crk, Efnb11, Efnb2, Fgfr11, Fgfr21, Fzd2, Gsk3b, Grb2, Jag1, Jag2, Pdgfra1, Pdgfc1, Vegfa, Wnt5a1
Family
Homeobox proteinAlx11, Barx1, Alx31, Alx41, Dlx1, Dlx2, Dlx51, Gbx2, Gsc, Hoxa21, Msx11, Msx21, Pax9, Prrx11, Pitx11, Pitx2, Rax, Shox2, Vax11
Tgf-beta receptor type I and IIAcvr1/Alk2, Acvr2a, Bmpr1a, Tgfbr1/Alk51, Tgfbr21
Tgf-beta familyBmp41, Bmp7, Gdf11, Inhba, Tgfb21, Tgfb31
Tyrosine protein kinaseEgfr, Fgfr11, Fgfr21, Pdgfra1, Ror21, Ryk
EphrinEfna5, Efnb11, Efnb2
Zinc finger proteinGli21, Gli31, Zic31, Hic1, Snai2
Forkhead proteinFoxc21, Foxd3, Foxe11, Foxf2
T-box proteinTbx11, Tbx2, Tbx221
Sox transcription factorSox5, Sox91, Sox11
Heparin-binding growth factor family member/FGFFgf9, Fgf10, Fgf18
SproutySpry1, Spry2
SmadSmad4, Smad7
Integrin beta subunitItgb1, Itgb8
FrizzledFzd2, Smo
Wnt relatedWnt5a1, Wnt9b
Serine-threonine protein kinaseIlk, Mpa3k7/Tak1
LIM domain containing proteinLhx81, Lhx7, Prickle1
EGF-like domain proteinJag1, Jag2