FoxO3a and disease progression

Figure 3 Forkhead box O3a localization by phosphorylation and dephosphorylation. Forkhead box O (FoxO)3a becomes translocated to the cytoplasm when phosphorylated on ser 253 residue by Akt or SGK. FoxO3a is then bound to 14-3-3 and this interaction promotes its degradation by the proteasome. In contrast, FoxO3a is dephosphorylated by protein phosphatase-2A and this opposite event facilitates its re-location into the nucleus, thereby activating its target genes. SGK: Serum-and glucocorticoid-induced protein kinase; Akt: Protein kinase B.