In 2014, can we do better than CA125 in the early detection of ovarian cancer?

Table 3 Results of serum marker panels for the detection of ovarian cancer

Serum marker(s)	Ref.	Sensitivity (%)	Specificity (%)
CA-125	1Karlsen et al[44]	91.7	75
	1Chan et al[47]	90.8	67.2
	1Leung et al[123]	89	90
	1Sandri et al[46]	84.4	80
	1Montagnana et al[54]	83	100
	1Sandri et al[46]	73.1	90
	Yang et al[55]	62.5	80
	Havrilesky et al[56]	45.9-58.5	98.2
	1Moore et al[37]	43.3	95
	Jacob et al[57]	12.5	90.1-93.9
HE-4	1Montagnana et al[54]	98	100
	Yang et al[55]	96.2	83.8
	1Karlsen et al[44]	91.3	75
	1Sandri et al[46]	83.1	90
	Havrilesky et al[56]	82.7-92.5	86.3
	1Moore et al[37]	72.9	95
	Jacob et al[57]	62.5	81.8-85.9
	1Chan et al[47]	56.9	96.9
CA-125, HE-4	1Moore et al[37]	76.4	95
	1Moore et al[41]	88.7	74.7
CA 125, leptin, PRL, OPN, IGFII, MIF	Visintin et al[58]	95.3	99.4
CA 125, CRP, SAA, IL-6, IL-8	Edgell et al[59]	94.1	91.3
CA-125, apoA-I, TTR, TF	Su et al[60]	89-97	91-99
CA 125, HE4, CEA, VCAM-1	Yurkovetsky et al[61]	86–93	98
CA 125, ApoA1, TTR	Kim et al[62]	93.9	95
	Zhang et al[42]	74	97
CA 125, CA 19-9, EGFR, CRP, myoglobin, ApoA1, ApoCIII, MIP-1a, IL-6, IL-18, tenascin C	1Amonkar et al[63]	91.3	88.5
CA-125, OVX1r, LASA,CA15-3, CA72-4	Nossov et al[11]	90.6	93.2
CA 125, CA 72-4, CA 15-3, M-CSF	1Skates et al[64]	70	98
LPA	Nossov et al[11]	90-100	90
FOLR1	1Leung et al[123]	62	90
M-CSF	Nossov et al[11]	61-68	93
SMRP	1Moore et al[37]	53.7	95

¹Study involved patients presenting with a pelvic mass; CA: Cancer antigen; HE-4: Human epididymis protein 4; PRL: Prolactin; OPN: Osteopontin; IGFII: Insulin-like growth factor II; MIF: Macrophage inhibitory factor; CRP: C-reactive protein; SAA: Serum amyloid A; IL: Interleukin; apoA-I: Apolipoprotein A-I; TTR: Transthyretin; TF: Transferrin; CEA: Carcinoembryonic antigen; VCAM-1: Vascular cell adhesion protein 1; EGFR: Epidermal growth factor receptor; ApoCIII: Apolipoprotein CIII; MIP-1a: Macrophage inflammatory protein-1alph; OVX1: Mouse antibody generated by immunizing mice with antigenic preparations from multiple OC cell lines[21]; LASA: Lipid-associated sialic acid; M-CSF: Macrophage colony-stimulating factor; LPA: Lipoprotein A; FOLR1: Folate receptor 1; SMRP: Soluble mesothelin-related peptide.