Can short-term fasting protect against doxorubicin-induced cardiotoxicity?

Table 1 Summary of unpublished data

Dependent variable	Control (mean ± SEM)	Dox (mean ± SEM)	P value
Aconitase activity (nmol/min per milligram protein)	14.46 ± 3.68	23.74 ± 3.25	0.08
SOD activity (units/mg protein)	0.026 ± 0.003	0.026 ± 0.002	0.904
SOD1 content	1025 ± 110.2	949 ± 91.6	0.603
SOD2 content	275.6 ± 23.25	288.1 ± 23.71	0.715
Procaspase-12 content	36.90 ± 6.14	24.28 ± 4.19	0.1
Procaspase-9 content	28.59 ± 1.57	25.33 ± 3.61	0.5
Procaspase-8 content	68.10 ± 11.90	82.90 ± 0.93	0.34
Caspase-3 activity (arbitrary OD/mg protein)	0.951 ± 0.676	0.490 ± 0.295	0.524
Caspase-9 activity (arbitrary OD/mg protein)	1.084 ± 0.809	0.462 ± 0.255	0.451
FIS1 content	563.6 ± 76.6	474.3 ± 68.8	0.4
DRP1 content	1294.9 ± 109.8	1187.5 ± 73.5	0.421
MFN1 content	5443.5 ± 786.8	4607.8 ± 627.0	0.417
MFN2 content	2001.5 ± 456.8	2053.6 ± 330.2	0.926
OPA1 content	6019.5 ± 739.3	6143.6 ± 601.0	0.897
PINK1 content	3343.0 ± 206.9	3422.0 ± 263.4	0.824
Parkin content	4192.0 ± 1009.0	4157.0 ± 1629.0	0.986
p62 content	1895.7 ± 272.7	1896.7 ± 252.2	0.998

Protein content determined by Western blot (units are “normalized OD”). SOD: Superoxide dismutase.