Role of PRMTs in cancer: Could minor isoforms be leaving a mark?

Table 1 Protein arginine methyltransferases in cancer cells

PRMT	Cancer type	Role(s) in cancer	Ref.
PRMT1	Breast cancer, Lung cancer, Colon cancer, Bladder cancer, Acute myeloid leukemia, Mixed lineage leukemia	Cell proliferation and survival, Transformation, Resistance to DNA damaging agents, Invasion	[13,15-17,19, 21,36-38]
PRMT2	Breast cancer	Cell proliferation and invasion	[22,72]
PRMT3	Breast cancer	Cell survival	[101,102]
CARM1/PRMT4	Breast cancer, Prostate cancer, Colorectal cancer	Cell proliferation	[12,14,77-79,88]
PRMT5	Lung cancer, Leukemia, Lymphoma, Melanoma, Gastric cancer, Colorectal cancer	Cell proliferation, Transformation, Invasion, Resistance to DNA damaging agents	[18,103-109]
PRMT6	Lung cancer, Bladder cancer	Cell proliferation	[17,110]
PRMT7	Breast cancer	Resistance to DNA damaging agents	[27,91,92,94]
PRMT8	ND	ND
PRMT9	ND	ND

ND: Not determined; PRMT: Protein arginine methyltransferase.