Role of Ikaros in T-cell acute lymphoblastic leukemia

Table 2 Studies of Ikaros status in human T-cell acute lymphoblastic leukemia

Study	No. of patients	Methods used	Cases with Ikaros abnormalities
Sun et al[30]	18 (pediatric)	WB, EMSA, IF, RT-PCR	18/18
Nakase et al[50]	5 (adult)	RT-PCR	0/5
Ruiz et al[51]	9 (pediatric)	RT-PCR, WB	0/9
Maser et al[52]	24 (16 cell lines and 8 primary leukemias)	CGH-array	2/24
Kuiper et al[53]	7 (unknown origin)	CGH-array	0/7
Meleshko et al[54]	14 (pediatric)	RT-PCR	1/14 (expression of dn Ik6 isoform)
Mullighan et al[6]	50 (unknown origin)	CGH-array	2/50
Marçais et al[31]	25 (adult, pediatric)	CGH-array, RT-PCR, WB, IF, cDNA sequencing	1/25

WB: Western blotting; EMSA: Electrophoretic mobility shift assay; IF: Immunofluorescence; RT-PCR: Reverse transcription polymerase chain reaction.