Physiological roles of mitogen-activated-protein-kinase-activated p38-regulated/activated protein kinase

Table 2 Mechanisms of the subcellular distribution of mitogen-activated protein kinase-activated protein kinase 5 mediated by its interaction partners

Nuclear export of MK5 mediated by	p38MAPK	ERK3	ERK4	PKA	Cdc14A
Importin1/NES-dependent	Yes	Yes	No	Yes	Not tested
Kinase activity MK5	Not required	Not required	Not required	required	Not tested
Phosphorylation of MK5 at T182A	Not required	Not required	Not required	required	Not tested
Catalytic activity partner	Not required	Not required	Not required	required	Not required
Ser-115-dependent	No	No	No	Yes	Not tested

MK5: Mitogen-activated protein kinase-activated protein kinase 5; ERK: Extracellular signal-regulated kinase; PKA: Protein kinase A; NES: Nuclear export signal.