Dual function of transforming growth factor beta 2 in the progression of gastric carcinoma

doi:10.4331/wjbc.121664

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World Journal of Biological Chemistry

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1949-8454

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Biol Chem. Sep 5, 2026; 17(3): 121664
Published online Sep 5, 2026. doi: 10.4331/wjbc.121664

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Figure 2 Survival. Survival rate of patients with gastric cancer was evaluated between the transforming growth factor beta 2 (TGFβ2)-high on cancer cells and -low on cancer-associated fibroblast (CAF) group, and the others group. Solid lines represent TGFβ2-positive on cancer cells and TGFβ2-negative on CAF, and dotted lines represent TGFβ2-negative on cancer cells or TGFβ2-positive on CAF. A: Both overall survival and recurrence-free survival curves showed a worse prognosis in the combination group after one year. Five-year overall survival indicated that TGFβ2-high on cancer cells and -low on CAF group showed significantly poor prognosis in compared to the other group (P = 0.0382); B: Recurrence-free survival showed that TGFβ2-high on cancer cells and -low on CAF group had a significant worse prognosis in compared to the other group (P = 0.0206). TGFβ2: Transforming growth factor beta 2; CAF: Cancer-associated fibroblast.

Citation: Imanishi D, Nishikubo H, Ma D, Sano T, Fan C, Sakuma T, Yashiro M. Dual function of transforming growth factor beta 2 in the progression of gastric carcinoma. World J Biol Chem 2026; 17(3): 121664
URL: https://www.wjgnet.com/1949-8454/full/v17/i3/121664.htm
DOI: https://dx.doi.org/10.4331/wjbc.121664

Imanishi D, Nishikubo H, Ma D, Sano T, Fan C, Sakuma T, Yashiro M. Dual function of transforming growth factor beta 2 in the progression of gastric carcinoma. World J Biol Chem 2026; 17(3): 121664 [DOI: 10.4331/wjbc.121664]

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