Dual function of transforming growth factor beta 2 in the progression of gastric carcinoma

Table 2 Univariate and multivariate statistics with survival (Cox proportional hazard regression analysis model)

Variables		Univariate	Multivariate
		P value	HR (95%CI)	P value
OS	Gender	0.9314	-	-
	His (tub: 0, por/sig: 1)	0.1137	-	-
	pT (pT1-3 vs pT4)	< 0.001	2.201 (1.5260-3.175)	< 0.001
	pN (pN0 vs pN1-3)	< 0.001	1.412 (0.9173-2.173)	0.117
	M (M0 vs M1)	< 0.001	3.140 (2.0720-4.758)	< 0.001
	inf (inf a-b vs inf c)	0.1699	-	-
	ly (ly0 vs ly1-3)	< 0.001	1.807 (1.1400-2.865)	0.01187
	v (v0 vs v1-3)	< 0.001	1.235 (0.8764-1.739)	0.2281
	TGFβ2 expression on cancer cell	0.1964	-	-
	TGFβ2 expression on CAF	0.5104	-	-
	TGFβ2 expression high on cancer cell and low on CAF or the others	0.03974	1.448 (0.9596-2.186)	0.07776
RFS	Gender	0.7913	-	-
	His (tub: 0, por/sig: 1)	0.5772	-	-
	pT (pT1-3 vs pT4)	< 0.001	2.457 (1.733-3.482)	< 0.001
	pN (pN0 vs pN1-3)	< 0.001	1.682 (1.124-2.516)	0.0114
	inf (inf a-b vs inf c)	0.1504	-	-
	ly (ly0 vs ly1-3)	< 0.001	1.613 (1.054-2.468)	0.0276
	v (v0 vs v1-3)	< 0.001	1.467 (1.037-2.074)	0.03025
	TGFβ2 expression on cancer cell	0.1639	-	-
	TGFβ2 expression on CAF	0.7394	-	-
	TGFβ2 expression high on cancer cell and low on CAF or the others	0.02194	1.637 (1.077-2.489)	0.02113

Univariate analyses were performed on overall survival and recurrence-free survival in 2-presents statistics for each parameter. Multivariate analyses were then performed on all variables that showed significant differences in the univariate analyses, and their independence factors were examined using the Cox proportional hazards model. CI: Confidence interval; HR: Hazard ratio; OS: Overall survival; TGFβ2: Transforming growth factor beta 2; CAF: Cancer-associated fibroblast; RFS: Recurrence-free survival; inf: Infiltration; ly: Lymphatic invasion; v: Vanous invasion.