Improved stabilisation of human pancreas biopsies: Comparative evaluation of RNA preservation methods

doi:10.4331/wjbc.121018

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World Journal of Biological Chemistry

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1949-8454

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Biol Chem. Sep 5, 2026; 17(3): 121018
Published online Sep 5, 2026. doi: 10.4331/wjbc.121018

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Figure 4 RNA integrity profiles of human pancreatic tissue across four preservation methods. The X-axis shows RNA fragment size (nucleotides) and the Y-axis shows normalised fluorescence intensity. Vertical markers left to right denote the lower internal size standard and the 18S and 28S ribosomal RNA subunit peaks. RNA integrity number (RIN) scale: 1 = fully degraded, 10 = fully intact. Representative electropherograms and traces displaying RNA integrity profiles of preserved human pancreatic tissue. A: Immediate processing (RIN = 5.0); B: Snap freezing (RIN = 2.8); C: Submersion in RNAlater (RIN = 7.8); D: RNAlater injection (RIN = 8.0). RIN^e: RNA integrity number^e; nt: Nucleotides.

Citation: Pook RR, Hearne A, Botting RA, Tingle SJ, Honkanen-Scott M, Shaw JAM, Ali S, Scott III WE. Improved stabilisation of human pancreas biopsies: Comparative evaluation of RNA preservation methods. World J Biol Chem 2026; 17(3): 121018
URL: https://www.wjgnet.com/1949-8454/full/v17/i3/121018.htm
DOI: https://dx.doi.org/10.4331/wjbc.121018

Pook RR, Hearne A, Botting RA, Tingle SJ, Honkanen-Scott M, Shaw JAM, Ali S, Scott III WE. Improved stabilisation of human pancreas biopsies: Comparative evaluation of RNA preservation methods. World J Biol Chem 2026; 17(3): 121018 [DOI: 10.4331/wjbc.121018]

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