Triggering receptor expressed on myeloid cells 2-driven pancreatic macrophage crosstalk: Key regulator of obesity pathophysiology and metabolic dysregulation

Table 1 Anatomical distribution: Peri-islet, acinar stroma, and ductal regions

Category	Core content	Ref.
Peri-islet region	This subpopulation is mainly located around and within pancreatic islets; macrophages in this region typically possess higher activity and antigen-presenting capacity, participating in islet immune surveillance and the regulation of insulin secretion	Calderon et al[7], 2015
Acinar stroma	Situated in the interstitial tissue between exocrine acini; this subpopulation of macrophages is relatively abundant, mainly involved in tissue homeostasis maintenance and injury repair, displaying stronger phagocytic ability and tissue repair functions	Unanue et al[8], 2016
Ductal region	Located around pancreatic ducts, particularly the larger ones; these macrophages may be associated with ductal secretory and defensive functions, and are closely linked to the occurrence and development of duct-related diseases	Calderon et al[7], 2015