Interferon-gamma signaling pathway: Modulation of key genes in the progression of glioblastoma

Figure 6 The molecular function of interferon-stimulated gene 15 and its relationship with glioblastoma. Interferon-stimulated gene 15 (ISG15) carries out its function through a post-translational modification similar to ubiquitination, known as ISGylation, which involves three steps: Activation, conjugation, and ligation of ISG15 to its target. The figure shows that this post-translational modification is reversible by ubiquitin-specific protease 18. ISG15 can be found both free and conjugated to its substrate, and, in the context of glioblastoma, it functions to enhance proliferation, migration, and invasion. ISG15: Interferon-stimulated gene 15; USP18: Ubiquitin-specific protease 18.