Interferon-gamma signaling pathway: Modulation of key genes in the progression of glioblastoma

doi:10.4331/wjbc.v16.i4.112768

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World Journal of Biological Chemistry

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1949-8454

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World J Biol Chem. Dec 5, 2025; 16(4): 112768
Published online Dec 5, 2025. doi: 10.4331/wjbc.v16.i4.112768

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Figure 5 The molecular function of indoleamine 2,3-dioxygenase 1 and its relationship with glioblastoma. Indoleamine 2,3-dioxygenase 1 is involved in the degradation of tryptophan into kynurenine and other toxic metabolites such as quinolinic acid; these metabolites function to suppress T-cell proliferation, thereby creating an immunosuppressed environment in glioblastoma. IDO1: Indoleamine 2,3-dioxygenase 1.

Citation: Oropeza-Martínez E, Palacios Serrato EG, Zamora-Salas SX, Lira-Rodríguez NA, López-Mignon SH, Martinez-Benitez MB, Tecalco-Cruz AC. Interferon-gamma signaling pathway: Modulation of key genes in the progression of glioblastoma. World J Biol Chem 2025; 16(4): 112768
URL: https://www.wjgnet.com/1949-8454/full/v16/i4/112768.htm
DOI: https://dx.doi.org/10.4331/wjbc.v16.i4.112768

Oropeza-Martínez E, Palacios Serrato EG, Zamora-Salas SX, Lira-Rodríguez NA, López-Mignon SH, Martinez-Benitez MB, Tecalco-Cruz AC. Interferon-gamma signaling pathway: Modulation of key genes in the progression of glioblastoma. World J Biol Chem 2025; 16(4): 112768 [PMID: 41378253 DOI: 10.4331/wjbc.v16.i4.112768]

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