Interferon-gamma signaling pathway: Modulation of key genes in the progression of glioblastoma

doi:10.4331/wjbc.v16.i4.112768

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World Journal of Biological Chemistry

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1949-8454

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Biol Chem. Dec 5, 2025; 16(4): 112768
Published online Dec 5, 2025. doi: 10.4331/wjbc.v16.i4.112768

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Figure 3 The molecular function of interferon regulatory factor 1 and its relationship with glioblastoma. Interferon regulatory factor 1 protein has the molecular function of a transcription factor; through this mechanism, it can positively regulate the gene expression of programmed death-ligand 1 and indoleamine 2,3-dioxygenase 1, promoting immune evasion and cell migration. IRF1: Interferon regulatory factor 1; PD-L1: Programmed death-ligand 1; IDO1: Indoleamine 2,3-dioxygenase 1; ISRE: Interferon-stimulated response element.

Citation: Oropeza-Martínez E, Palacios Serrato EG, Zamora-Salas SX, Lira-Rodríguez NA, López-Mignon SH, Martinez-Benitez MB, Tecalco-Cruz AC. Interferon-gamma signaling pathway: Modulation of key genes in the progression of glioblastoma. World J Biol Chem 2025; 16(4): 112768
URL: https://www.wjgnet.com/1949-8454/full/v16/i4/112768.htm
DOI: https://dx.doi.org/10.4331/wjbc.v16.i4.112768

Oropeza-Martínez E, Palacios Serrato EG, Zamora-Salas SX, Lira-Rodríguez NA, López-Mignon SH, Martinez-Benitez MB, Tecalco-Cruz AC. Interferon-gamma signaling pathway: Modulation of key genes in the progression of glioblastoma. World J Biol Chem 2025; 16(4): 112768 [PMID: 41378253 DOI: 10.4331/wjbc.v16.i4.112768]

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