Intramuscular injection of therapeutic botulinum toxin facilitates blood coagulation in experimental aging mice

Figure 1 Botulinum toxin treatment reduced bleeding time and loss of blood upon tail tip transection. A: Representative image of bleeding assay during the tail tip amputation of an experimental mouse; B: The differences in the blood loss from the tail tip cut of a control and Botulinum toxin (BoNT)-treated mouse in the prewarmed saline containing tubes; C: Tail bleeding time; D: Total bleeding duration; E: Difference in body weight before and after the tail bleeding assay; F: The estimated volume of blood loss in control and BoNT-treated animals. ^aP value ≤ 0.01, ^bP value ≤ 0.001. BoNT: Botulinum toxin.