Molecular and cellular mechanisms of pentadecanoic acid

Figure 2 Integrated signaling network engaged by pentadecanoic acid. Colored arrows denote directionality (open triangle: Activation; blunt: Inhibition). Numeric annotations indicate representative potencies or efficacies extracted from in-cell assays. AMPK: AMP-activated protein kinase; C15:0: Pentadecanoic acid; EC₅₀: Half-maximal activation; JAK: Janus kinase; HDAC6: Histone deacetylase 6; mTOR: Mechanistic target of rapamycin; NF-κB: Nuclear factor kappa B; PPARα/δ: Peroxisome proliferator-activated receptor α/δ; STAT3: Signal transducer and activator of transcription 3.