Association between Alzheimer's disease and Porphyromonas gingivalis products in murine models: A systematic review

Table 2 Classification of the factors involved in the evolution of Alzheimer's

Types of factors	Factors	Quantity
Glial cells	Astrocytes	6
	Microglia	9
Immune cells	Lymphocytes	2
	Macrophages	1
	Monocytes	1
	Th1/Th17	1
	Myeloid cells	1
Cytokine	IL-1β	3
	IL-6	2
	Interleukins	1
	TGF-β1	1
	TNF-α	3
	IL-17	1
Enzyme	ADAM10	1
	BACE1	1
	CatB	1
	COX-2	1
	NOS	1
	PP2A (phosphorylated/inactive)	1
Structural	BBB	1
	Circulatory system	1
	Brain	1
Transcription factor	NF-κB	2
	Nrf2/HO-1	1
	STAT3	1
Essential minerals	Trace elements	1
Neurons	Trigeminal neurons	1
Peptide	Amyloid-β	3
Protein	Albumin	1
	Caveolin1	1
	Cofilina-2	1
	GFAP	1
	MFSD2A	1
	Presenilin	1
	SCPPPQ1	1
	Caveolar vesicles	1
	APP	2
	Tau	1
	CD36	1
	CD204	1
Kinases	JAK2	1
	GSK3β	1
PRR	TLR	1
	TLR2	1
	TLR4	2
	TLR2	1
Complement system	C1q	1
	C3	1
	C5	1
Marker	CD3	1
	Iba-1	2
Bacteria	Lactobacillus sp.	1
	Dysbiotic gut microbiota	1

Th1/Th17: T helper type 1/17 cells; IL: Interleukins; TGF-β1: Transforming growth factor beta 1; TNF-α: Tumor necrosis factor alpha; ADAM10: A disintegrin and metalloproteinase domain-containing protein 10; BACE1: Beta-site amyloid precursor protein cleaving enzyme 1; CatB: Cathepsin B; COX-2: Cyclooxygenase-2; NOS: Nitric oxide synthase; BBB: Blood-brain barrier; NF-κB: Nuclear factor kappa-light-chain-enhancer of activated B cells; Nrf2/HO-1: Nuclear factor erythroid 2-related factor 2/heme oxygenase 1; STAT3: Signal transducer and activator of transcription 3; GFAP: Glial fibrillary acidic protein; MFSD2A: Major facilitator superfamily domain-containing protein 2A; SCPPPQ1: Secretory calcium-binding phosphoprotein proline-glutamine rich 1; APP: Amyloid precursor protein; CD: Cluster of differentiation; JAK2: Janus kinase 2; GSK3β: Glycogen synthase kinase 3 beta; TLR: Toll-like receptor; C1q, C3, C5: Complement components 1q, 3, and 5; Iba-1: Ionized calcium-binding adaptor molecule 1.