Macrophage-mediated metabolic dysregulation in the pancreas: Insights from obesity

doi:10.4331/wjbc.v16.i4.109509

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World Journal of Biological Chemistry

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1949-8454

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Biol Chem. Dec 5, 2025; 16(4): 109509
Published online Dec 5, 2025. doi: 10.4331/wjbc.v16.i4.109509

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Figure 2 Role of pancreatic macrophages in obesity-associated metabolic dysregulation. This figure delineates the pathway-mediated process by which islet macrophages polarize into M1 and M2 phenotypes under inflammatory conditions, secreting pro-inflammatory cytokines that ultimately lead to β-cell loss. CCL2: Chemokine (C-C Motif) Ligand 2; HIF-1α: Hypoxia-inducible factor-1 alpha; 12-LOX: 12-lipoxygenase; SUCLA2: Succinate-CoA ligase ADP-forming beta subunit; TGF-β: Transforming growth factor-beta; TNF-α: Tumor necrosis factor-alpha; IL-1β: Interleukin-1 beta

Citation: Chen KR, Chen ZY, Liu FY, Xie CY, Hu J, Wang SY, Xu B, Xu TC. Macrophage-mediated metabolic dysregulation in the pancreas: Insights from obesity. World J Biol Chem 2025; 16(4): 109509
URL: https://www.wjgnet.com/1949-8454/full/v16/i4/109509.htm
DOI: https://dx.doi.org/10.4331/wjbc.v16.i4.109509

Chen KR, Chen ZY, Liu FY, Xie CY, Hu J, Wang SY, Xu B, Xu TC. Macrophage-mediated metabolic dysregulation in the pancreas: Insights from obesity. World J Biol Chem 2025; 16(4): 109509 [PMID: 41378249 DOI: 10.4331/wjbc.v16.i4.109509]

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