Remission is not maintained over 2 years with hematopoietic stem cell transplantation for rheumatoid arthritis: A systematic review with meta-analysis

Table 1 Methodological quality and risk of bias assessment of the included studies (n = 17)

Randomized controlled trial
			Ref.	Randomization process	Deviation from the intended interventions	Missing outcome data	Measurement of the outcome	Selection of the reported result	Overall Bias
			Moore et al[13]	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk
Prospective studies
	Ref.			A clearly stated aim	Inclusion of consecutive patients	Prospective collection of data	Endpoints appropriate to the aim of the study	Unbiased assessment of the study endpoint	Follow-up period appropriate to the aim of the study	Loss to follow up less than 5%	Prospective calculation of the study size
	Tyndall et al[29]			1	1	2	2	2	1	2	1
	Burt et al[26]			2	2	2	1	2	1	2	1
	Burt et al[25]			2	2	2	1	2	1	2	1
	Verburg et al[30]			2	2	2	2	2	2	2	1
	Snowden et al[27]			2	2	2	1	2	1	2	1
	van Laar et al[28]			2	2	2	2	2	2	2	1
	Snowden et al[15]			1	1	2	1	2	1	2	1
	Bingham et al[11]			2	2	2	2	2	2	2	1
	Teng et al[9]			2	2	2	2	2	2	2	1
	Pavletic et al[31]			2	2	2	2	2	2	2	1
	Verburg et al[32]			2	2	2	2	2	2	2	1
Case reports
		Ref.		Selection score	Ascertainment score	Causality score	Reporting score	Total score
		Silva et al[12]		1	2	1	1	5
		Joske et al[33]		1	1	1	1	4
		Kim et al[35]		1	2	1	1	5
		Durez et al[34]		1	1	1	1	4
		Burt et al[36]		1	2	1	1	5