Editorial
Copyright ©2010 Baishideng Publishing Group Co.
World J Biol Chem. Jul 26, 2010; 1(7): 209-220
Published online Jul 26, 2010. doi: 10.4331/wjbc.v1.i7.209
Figure 4
Figure 4 Effect of DNA repair systems on poly(ADP-ribose) polymerase activity. Double-strand breaks (DSBs) lead to the activation of poly(ADP-ribose) polymerases (PARPs). PARP plays a key role in the repair of SSBs. Treatment with a PARP inhibitor induces DSBs and selectively kills homologous recombination (HR)/breast and ovarian cancer susceptibility gene (BRCA)-deficient cells.