Soluble and insoluble signals sculpt osteogenesis in angiogenesis

Figure 14 Complete regeneration of a calvarial defect in P. ursinus 365 d after implantation of a macroporous construct of hydroxyapatite/β-tricalcium phosphate. Long term incorporation of the biphasic biomimetic matrix within the calvarium showing restitutio ad integrum of the calvarial defect; long arrows indicate the defect margins showing bone formation by induction across the macroporous spaces with the newly generated bone higher than the recipient calvarium; short arrow indicates the overlying temporalis muscle. Decalcified section cut at 6 μm.