Therapeutic improvement of colonic anastomotic healing under complicated conditions: A systematic review

Table 6 Studies on therapeutic compounds in models of radiotherapy

Ref.	Compound	Time of administration	Species	Sex	Sample size1	Dosage	Route	Test	Test day	Effect2
Demir et al[96]	NAC	Preoperative and postoperative	Rat	M	24	3005	PO/IP	BPR	4	↑ 126/↑ 182
Ozdemir et al[94]	Amifostine	Preoperative	Rat	F	20	2005	IP	BPR	5	↑ 16
Carroll et al[93]	Ribose-cysteine3	Preoperative	Rat	M	72	20005	IP	BPR	7	↑ 50
	Ribose-cysteine4	Preoperative				50005	IP			N/A
	Ribose-cysteine3 + glutamine3	Preoperative and postoperative				20005 + 36	IP + PO			NS
	Amifostine3	Preoperative				2505	IP			↑ 46
	Amifostine4	Preoperative				2505	IP			NS
	MgCl23 + ATP3	Preoperative				107 + 507	iv			↑ 67
Rowe et al[97]	Ribose-cysteine	Preoperative	Pig	M	12	10005	iv	BPR	9/11	NS
Değer et al[27]	Pycnogenol	Preoperative	Rat	M	40	2005	PO	BPR	3/7	↑ 19/↑ 38
Ozel Turkcu et al[95]	EPO	Preoperative and postoperative	Rat	M	16	5008	IM	BPR	N/A	NS

¹Total number of animals;

²↑% increase (P < 0.05) vs controls;

³40 GY;

⁴70 GY;

⁵mg/kg;

⁶%-solution;

⁷g/kg;

⁸IU/kg. ATP: Adenosine triphosphate; BPR: Bursting pressure; EPO: Erythropoietin; F: Female; IM: Intramuscular; IP: Intraperitoneal; iv: Intravenous; M: Male; NAC: N-acetyl cysteine; N/A: Data not available; NS: Not statistically significant; PO: Per os.