Therapeutic improvement of colonic anastomotic healing under complicated conditions: A systematic review

Table 4 Studies on therapeutic compounds in models of peritonitis

Ref.	Compound	Time of administration	Species	Sex	Sample size1	Dosage	Route	Test	Test day	Effect2
Ayten et al[67]	Sildenafil	Postoperative	Rat	F	14	83	IP	BPR	7	↑ 43
Diller et al[74]	ATIII	Intraoperative	Mouse	M	60	2504	iv	BPR	2	↑ 34
									4	NS
									7	↑ 38
Gunerhan et al[72]	UFH	Postoperative	Rat	M	45	503	SC	BPR	7	↑ 12
	LMWH					1.53				↑ 19
Onur et al[76]	Ethyl pyruvate	Postoperative	Rat	N/A	20	503	IP	BPR	7	↑ 51
Aytekin et al[68]	Tempol	Preoperative and postoperative	Rat	M	20	303	iv	BPR	6	↑ 10
Ergin et al[75]	G-CSF	Preoperative and postoperative	Rat	M	20	0.0503	SC	BPR	4	↑ 26
	Levamisole				20	53	PO			NS
Teke et al[69]	Activated protein C	Preoperative and postoperative	Rat	M	24	0.13	iv	BPR	7	↑ 9
Teke et al[70]	Caffeic acid phenethyl ester	Preoperative and postoperative	Rat	M	24	0.00283	IP	BPR	7	↑ 9
Teke et al[71]	Pyrrolidine dithiocarbamate	Preoperative and postoperative	Rat	M	20	1003	iv	BPR	6	↑ 7
Akkuş et al[73]	Taurolidine	Intraoperative	Rat	F	40	0.55	Lavage	BPR	3/7	↑ 26/↑ 12
Bicalho et al[78]	Chlorhexidine	Intraoperative	Rat	M	16	0.055	Lavage	BPR	7	NS
Wang et al[79]	Hydroxyethyl starch	Preoperative and postoperative	Rat	M	32	7.56	iv	BPR	5	NS
						156				↑ 9
						306				↓ 5
Wang et al[80]	Hydroxyethyl starch	Preoperative and postoperative	Rat	M	20	156	iv	BPR	5	↑ 9
Sucullu et al[81]	HBOT	Postoperative	Rat	M,F	32			BPR	3/7	↑ 186/↑ 74
Rocha et al[82]	HBOT	Postoperative	Rat	M	30			BST	5	NS
Vaneerdeweg et al[83]	Gentamicin	Intraoperative	Rat	M	30	2.67/123	LO/IM	BPR	4	NS/NS

¹Total number of animals;

²↑% increase (P < 0.05) or ↓% decrease (P < 0.05) vs controls;

³mg/kg;

⁴IU/kg;

⁵%-solution;

⁶mL/kg;

⁷mg. ATIII: Antithrombin III; BPR: Bursting pressure; BST: Breaking strength; F: Female; G-CSF: Granulocyte-colony stimulating factor; HBOT: Hyperbaric oxygen therapy; IM: Intramuscular; IP: Intraperitoneal; iv: Intravenous; LMWH: Low molecular weight heparin; LO: Local; M: Male; N/A: Data not available; NS: Not statistically significant; PO: Per os; SC: Subcutaneous; UFH: Unfractionated heparin.