Therapeutic improvement of colonic anastomotic healing under complicated conditions: A systematic review

Table 2 Studies on therapeutic compounds in ischemia/reperfusion injury models

Ref.	Compound	Time of administration	Species	Sex	Sample size1	Dosage	Route	Test	Test day	Effect2
Tekin et al[56]	ATIII	Preoperative and postoperative	Rat	M	16	2503	iv	BPR	6	↑ 74
Unal et al[57]	Ethyl pyruvate	Preoperative	Rat	M	24	504	IP	BPR	5	↑ 63
		Preoperative and postoperative								↑ 69
Kabali et al[53]	NAC	Preoperative	Rat	F	30	3004	PO/IP	BPR	7	↑ 25/↑ 37
Aydin et al[55]	Tempol	Preoperative and postoperative	Rat	M	20	304	iv	BPR	5	↑ 6
Teke et al[58]	Activated protein C	Preoperative and postoperative	Rat	M	24	0.14	iv	BPR	7	↑ 7
Teke et al[59]	Caffeic acid phenethyl ester	Preoperative and postoperative	Rat	M	24	0.00284	iv + IP	BPR	7	↑ 7
Teke et al[54]	Pyrrolidine dithiocarbamate	Preoperative and postoperative	Rat	M	20	1004	iv	BPR	6	↑ 6
Celik et al[52]	Montelukast	Preoperative and postoperative	Rat	M	24	104	IP	BPR	5	↑ 36

¹Total number of animals;

²↑% increase (P < 0.05) vs controls;

³IU/kg;

⁴mg/kg; ATIII: Antithrombin III; BPR: Bursting pressure; F: Female; IP: Intraperitoneal; iv: Intravenous; M: Male; NAC: N-acetyl cysteine; PO: Per os.