Therapeutic improvement of colonic anastomotic healing under complicated conditions: A systematic review

Table 1 Studies on therapeutic compounds in ischemic models

Ref.	Compound	Time of administration	Species	Sex	Sample size1	Dosage	Route	Test	Test day	Effect2
Yagci et al[33]	HBOT	Preoperative	Rat	M	20			BPR	5	NS
		Postoperative			20					↑ 23
		Preoperative and postoperative			20					↑ 37
Hamzaoğlu et al[31]	HBOT	Postoperative	Rat	M	16			BPR	4	↑ 32
Guzel et al[35]	HBOT	Postoperative	Rat	F	20			BPR	4	↑ 50
	HBOT + β-1,3-glucan				20	203	IP			↑ 67
	β-1,3-glucan				20	203	IP			↑ 50
Kemik et al[36]	HBOT	Postoperative	Rat	F	20			BPR	4	↑ 80
	HBOT + LMWH				20	14	SC			↑ 67
	LMWH				20	14	SC			NS
Adas et al[21]	VEGF-A plasmid	Intraoperative	Rat	M	40	0.0013	LO	BPR	4	↑ 16
	FGF-2 plasmid					0.0013				↑ 14
	VEGF-A + FGF-2 plasmids					0.0013 + 0.0013				↑ 38
Saribeyoğlu et al[38]	PDGF-BB	Intraoperative	Rat	M	20	1253	LO	BPR	4	↑ 8
Yarimkaya et al[32]	GH	Preoperative and postoperative	Rat	M	28	15	SC	BPR	3/7	↑ 87/↑ 32
	Nandrolone	Preoperative			28	24	IM			↑ 55/NS
Tasdelen et al[39]	Leptin	Postoperative	Rat	N/A	20	0.0014	IP	BPR	7	↑ 27
Parra-Membrives et al[34]	Pentoxifylline	Postoperative	Rat	M, F	38	504	IP	BPR/BST	8	↑ 74/↑ 81
Sümer et al[40]	Pentoxifylline	Postoperative	Rat	M, F	20	504	IP	BPR	5	NS
	Vinpocetine				20	14				NS
Karatepe et al[41]	Adrenomedullin	Postoperative	Rat	F	32	0.0023	SC	BPR	3/7	↑ 5/↑ 20
Cetinkaya et al[43]	Bostentan	Postoperative	Rat	F	20	3.54	IP	BPR	6	↑ 46
Garcia et al[22]	Allopurinol	Preoperative and postoperative	Rat	M	20	504	PO	BPR	4	↑ 74
Adas et al[44]	MSCs	Intraoperative	Rat	M	40	0.56	LO	BPR	4/7	↑ 110/↑ 86
Adas et al[45]	MSCs	Postoperative	Rat	M	40	0.56	iv	BPR	4/7	↑ 42/NS
Dinc et al[46]	GM-CSF	Intraoperative	Rat	M	72	0.0504	LO	BPR	3/7	↑ 30/↑ 26
Ikeda et al[47]	Prostacyclin analogue (OP-41483)	Intraoperative and postoperative	Dog	M, F	107	0.000044	iv	AL	3	NS
					188					↓ 100
					129					NS
Cohen et al[48]	Neomycin + erythromycin	Preoperative	Rat	N/A	12	203	PO	AL	7	↓ 83
	Clindamycin + gentamicin				12	154 + 24	iv			NS
Karataş et al[49]	Amelogenin	Intraoperative	Rat	M	16	N/A	LO	BPR	4	↑ 25
Irkorucu et al[50]	Sildenafil	Postoperative	Rat	M	27	104/204	PO	BPR	4	NS/NS
Coneely et al[51]	Compound 48/80	Preoperative	Rat	M	20	14	iv	BPR	4	NS

¹Total number of animals;

²↑% increase (P < 0.05) or ↓% decrease (P < 0.05) vs controls;

³mg;

⁴mg/kg;

⁵IU/kg;

⁶mL;

⁷Slight ischemia;

⁸Moderate ischemia;

⁹Severe ischemia. AL: Anastomotic leakage; BPR: Bursting pressure; BST: Breaking strength; F: Female; FGF-2: Fibroblast growth factor-2; GH: Growth hormone; GM-CSF: Granulocyte macrophage-colony stimulating factor; HBOT: Hyperbaric oxygen therapy; IP: Intraperitoneal; iv: Intravenous; LMWH: Low molecular weight heparin; LO: Local; M: Male; MSCs: Bone marrow derived mesenchymal stem cells; N/A: Data not available; NS: Not statistically significant; PDGF-BB: Platelet-derived growth factor-BB; PO: Per os; SC: Subcutaneous; VEGF-A: Vascular endothelial growth factor-A.