Laparoscopic liver resection: Experience based guidelines

Table 4 Comparative studies of laparoscopic and open liver resection for hepatocellular carcinoma including more than 30 patients in each arm

Ref.	No. of patients		Blood loss (mean/median, mL)			Blood transfusion (%)			Conversion (%)	Complication (%)			Perioperative mortality (%)			5-yr overall survival (%)			5-yr recurrence free survival (%)
	LLR	OLR	LLR	OLR	P value	LLR	OLR	P value		LLR	OLR	P value	LLR	OLR	P value	LLR	OLR	P value	LLR	OLR	P value
Belli et al[34]	54	125	297	580	< 0.01	11	25.6	0.03	7	19	36	0.02	2	4	NS	671	-	NS	521	-	NS
Tranchart et al[35]	42	42	364	723	< 0.0001	9.5	16.7	NS	4.7	21.4	40.5	NS	2.4	2.4	NS	59.51	47.41	NS	60.91	54.31	NS
Truant et al[36]	36	61	452	447	NS	2.8	3.8	NS	19.4	25	35.8	NS	0	7.5	NS	70	46	NS	35.5	33.6	NS
Lee et al[37]	33	50	150	240	NS	6.1	10	NS	18.2	6.1	24	0.033	0	0	NS	76	76.1	NS	45.3	55.9	NS
Hu et al[110]	30	30	520 g	480 g	NS	NA	NA	-	0	13.3	10	NS	0	0	NS	50	50.3	NS	NR	NR	-
Ker et al[38]	116	208	139	1147	< 0.001	6.9	50.9	< 0.001	5.2	6	30.2	< 0.001	0	2.9	NS	62.2	71.8	NS	NR	NR	-
Cheung et al[39]	32	64	150	300	0.001	0	4.7	NS	NR	6.3	18.8	NS	0	1.6	NS	76.6	57	NS	54.5	44.3	NS
Ai et al[40]	97	178	460	454	NS	4.6	2.8	NS	9.28	9	30	0.001	0	0	NS	861	881	NS	661	671	NS
Memeo et al[41]	45	45	200	200	NS	0	0	NS	NR	20	45	0.01	2	13	0.04	59	44	NS	19	23	NS
Kim et al[42]	70	70	NA	NA	-	24.3	40.8	0.001	8.57	7.1	14.5	NS	NR	NR	-	65.3	65.7	NS	58.3	62.6	NS
Kim et al[198]	43	162	484	261	NS	3.4	0	NS	23.3	13.8	37.9	NS	0	0	NS	92.2	87.7	NS	54	40.1	NS
Ahn et al[43]	51	51	350	355.2	NS	5.9	9.8	NS	Excluded	5.8	9.8	NR	0	0	NS	80.1	85.7	NS	67.8	54.8	NS
Yamashita et al[44]	63	99	455	436	NS	6	2	NS	NA	10	26	0.046	0	0	NS	69	77	NS	33	41	NS
Yoon et al[45]	58	174	NA	NA	-	3.4	7.5	0.04	0	6.9	22.4	0.02	NR	NR	-	882	682	NS	562	622	NS
Martin et al[46]	100	254	336	755	< 0.001	1.2	2.4	0.043	NR	44	57	NS	6	8	NS	60.71	41.81	NS	201	261	NS
Lee et al[47]	43	86	300	700	0.004	NR	NR	-	14	23.3	39.5	NS	NR	NR	-	89.7	87.3	NS	53.5	58.6	NS
Han et al[48]	88	88	500	525	NS	20	26.1	NS	9.1	12.5	20.4	0.042	1.1	1.1	NS	76.4	73.2	NS	44.2	41.2	NS
Xiao et al[49]	41	86	272.2	170.8	0.001	7.3	13.9	NS	7.32	17.1	37.3	0.021	0	0	NS	781	76.71	NS	70.71	68.61	NS

¹Data computed for 3-yr survival;

²Data computed for 4-yr survival. LLR: Laparoscopic liver resection; OLR: Open liver resection; NR: Not reported; NS: Non significant.