Colorectal cancer risk in hamartomatous polyposis syndromes

doi:10.4240/wjgs.v7.i3.25

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Mar 27, 2015 (publication date) through Apr 25, 2024

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Surg. Mar 27, 2015; 7(3): 25-32
Published online Mar 27, 2015. doi: 10.4240/wjgs.v7.i3.25

Table 1 Genetic features and prevalence of pure Hamartomatous Polyposis Syndromes

Syndrome	Mode of inheritance	Gene	Incidence
Juvenile Polyposis	AD	SMAD4/DPC4BMPR1A	1:100 to 1:160 thousand
Peutz-Jeghers	AD	STK11/LKB1	1:60 mil a 1:300 thousand
BRRS	AD	PTEN	Rare
Cowden	AD	PTEN, SDH and KLLN epimutations	1:200 thousand

BRRS: Bannayan-Riley-Ruvalacaba syndrome; AD: Autosomal dominant; SDH: Succinate dehydrogenase (B and C subunits); KLLN: p53 target gene.

Citation: Campos FG, Figueiredo MN, Martinez CAR. Colorectal cancer risk in hamartomatous polyposis syndromes. World J Gastrointest Surg 2015; 7(3): 25-32
URL: https://www.wjgnet.com/1948-9366/full/v7/i3/25.htm
DOI: https://dx.doi.org/10.4240/wjgs.v7.i3.25