Matched analysis of long-term oncological outcomes between watch-and-wait strategy and radical surgery after neoadjuvant therapy for rectal cancer

doi:10.4240/wjgs.121131

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Surg. Sep 27, 2026; 18(9): 121131
Published online Sep 27, 2026. doi: 10.4240/wjgs.121131

Table 3 Comparison of quality of life scores between the watch-and-wait and radical surgery groups, mean ± SD

Scale	Domain	Watch-and-wait group (n = 42)	Radical surgery group (n = 42)	t value	P value
QLQ-C30	Global health status	82.45 ± 9.14	75.69 ± 10.34	3.229	0.002
	Physical functioning	88.23 ± 8.56	85.74 ± 9.88	1.256	0.212
	Role functioning	86.92 ± 10.28	80.13 ± 12.42	2.783	0.007
	Emotional functioning	84.54 ± 11.37	78.07 ± 13.65	2.373	0.020
	Cognitive functioning	87.11 ± 9.85	84.36 ± 11.09	1.198	0.234
	Social functioning	83.63 ± 12.17	76.45 ± 14.58	2.466	0.016
	Fatigue symptom	12.84 ± 9.59	18.95 ± 11.23	2.705	0.008
	Pain symptom	8.35 ± 7.13	13.67 ± 9.86	2.880	0.005
	Insomnia symptom	10.26 ± 8.48	16.78 ± 12.05	2.915	0.005
QLQ-CR29	Urinary problems	15.42 ± 10.84	22.12 ± 13.55	2.554	0.012
	Diarrhea	16.75 ± 12.40	25.34 ± 14.97	2.936	0.004
	Bowel function problems	18.26 ± 11.62	21.53 ± 13.88	1.200	0.233

QLQ-C30: Quality of Life Questionnaire-Core 30; QLQ-CR29: Quality of Life Questionnaire-Colorectal Cancer Module (29 items).

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Citation: Li ZJ, Zhang K. Matched analysis of long-term oncological outcomes between watch-and-wait strategy and radical surgery after neoadjuvant therapy for rectal cancer. World J Gastrointest Surg 2026; 18(9): 121131
URL: https://www.wjgnet.com/1948-9366/full/v18/i9/121131.htm
DOI: https://dx.doi.org/10.4240/wjgs.121131