Oxycodone-dexmedetomidine vs fentanyl analgesia in septic patients after gastric perforation surgery

Table 6 Comparison of lactate metabolism between two groups, mean ± SD

Item	Control group (n = 49)	Intervention group (n = 49)	t value	P value
Lactate on admission (mmol/L)	4.8 ± 1.6	4.6 ± 1.5	0.634	0.528
Lactate at 12 hours (mmol/L)	3.6 ± 1.2	2.8 ± 0.9	3.712	< 0.001
Lactate at 24 hours (mmol/L)	2.9 ± 1.0	2.1 ± 0.7	4.542	< 0.001
Lactate at 48 hours (mmol/L)	2.2 ± 0.8	1.6 ± 0.5	4.412	< 0.001
24h lactate clearance rate (%)	38.6 ± 14.8	52.8 ± 12.4	5.102	< 0.001
Time to lactate normalization (hours)	46.8 ± 14.2	32.4 ± 10.6	5.632	< 0.001

Lactate clearance rate = [(initial lactate - current lactate)/initial lactate] × 100%.