Meta-analysis of surgical quality-related factors associated with local recurrence rate after rectal cancer surgery

Figure 3 Subgroup analysis of circumferential resection margin status and local recurrence by neoadjuvant therapy use. Subgroup analysis stratified by neoadjuvant therapy demonstrated consistent associations between positive circumferential resection margin and increased local recurrence risk, both in patients receiving neoadjuvant therapy [odds ratio (OR) = 4.15] and those undergoing primary surgery (OR = 4.48), with no significant interaction between subgroups (P for interaction = 0.68). 95%CI: 95% confidence interval.