Impact of target volume delineation accuracy on locoregional control and survival after postoperative radiotherapy for colorectal cancer

doi:10.4240/wjgs.117559

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Surg. Aug 27, 2026; 18(8): 117559
Published online Aug 27, 2026. doi: 10.4240/wjgs.117559

Table 6 Univariate analysis of factors affecting overall survival

Factor	HR	95%CI	P value
Gender (male vs female)	1.268	0.698-2.304	0.436
Age (> 60 years vs ≤ 60 years)	1.395	0.774-2.516	0.268
ECOG score (2 vs 0-1)	1.684	0.782-3.626	0.182
Tumor location (colon vs rectum)	0.856	0.465-1.576	0.619
Differentiation (poor vs moderate-well)	1.538	0.762-3.104	0.229
pT stage (T4 vs T3)^a	1.982	1.096-3.584	0.023^a
pN stage (N2 vs N0-1)^a	2.156	1.268-3.666	0.004^a
Lymph node metastasis (N+ vs N0)^a	2.034	1.205-3.434	0.008^a
Vascular invasion (yes vs no)^a	1.658	0.928-2.964	0.089^a
Neural invasion (yes vs no)^a	1.812	1.022-3.213	0.042^a
Margin status (positive vs negative)^a	2.486	1.352-4.572	0.003^a
Preoperative CEA (elevated vs normal)^a	1.746	1.036-2.944	0.036^a
Preoperative CA19-9 (elevated vs normal)	1.462	0.802-2.665	0.214
Surgical approach (laparoscopic vs open)	0.795	0.444-1.424	0.442
Neoadjuvant therapy (yes vs no)	0.728	0.362-1.465	0.374
Chemotherapy regimen (single vs combination)	1.318	0.725-2.397	0.364
Target delineation (inaccurate vs accurate)^a	2.542	1.426-4.532	0.001^a

^aP < 0.10, included in multivariate analysis.

HR: Hazard ratio; CI: Confidence interval; CEA: Carcinoembryonic antigen; CA19-9: Carbohydrate antigen 19-9; ECOG: Eastern Cooperative Oncology Group.

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Citation: Xing Y, Gu M. Impact of target volume delineation accuracy on locoregional control and survival after postoperative radiotherapy for colorectal cancer. World J Gastrointest Surg 2026; 18(8): 117559
URL: https://www.wjgnet.com/1948-9366/full/v18/i8/117559.htm
DOI: https://dx.doi.org/10.4240/wjgs.117559